Originally posted by AThousandYoungOf course not. Given that humans, when given the chance, tend to breed like rabbits, it doesn't even count as depopulating the Earth. We'll be back after a century or two, no problems.
I wonder how destroying the world is defined. Suppose there was an apocalyptic war but people in bunkers survived. Does that count?
Having the whole planet eaten by a Great Old One would probably suffice. Probably.
Richard